Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Nebivolol might be Beneficial in Osteoporosis Treatment: A Hypothesis

Aysun Toker¹, Erim Gulcan² , Serdar Toker³, Enver Erbilen⁴, Elif Aksakalli⁵

¹Department of Biochemistry and Clinical Biochemistry, Yoncali Physical Therapy and Hydrotheraphy Hospital; ²Department of Internal Medicine; ³Department of Orthopaedics and Traumatology; ⁴Department of Cardiology; ⁵Department of Physical Therapy and Rehabilitation, Dumlupinar University Faculty of Medicine, Kutahya, Turkey.

For correspondence:- Erim Gulcan Email: drerimgulcan@gmail.com

Received: 22 September 2008 Accepted: 22 November 2008 Published: 17 April 2009

Citation: Toker A, Gulcan E, Toker S, Erbilen E, Aksakalli E. Nebivolol might be Beneficial in Osteoporosis Treatment: A Hypothesis. Trop J Pharm Res 2009; 8(2):181-186 doi: 10.4314/tjpr.v8i2.12

© 2009 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Nebivolol is a β-blocker that is highly selective for β1-adrenergic receptors with vasodilating properties. This property can be attributed to an endothelial release of nitric oxide (NO). It has been reported that nebivolol also reduces intracellular oxidative stress. There are some studies conducted in humans and animal models which have shown that NO is an important regulator of bone metabolism. However, oxidative stress and antioxidant systems may play important roles in the pathogenesis of osteoporosis. In this paper, we hypothesized that nebivolol may have beneficial effects via nitric oxide and antioxidant action in osteoporosis treatment.

Keywords: Osteoporosis treatment, Nebivolol, Nitric oxide, Anti-oxidant action